Clinical and immunologic impact of CCR5 blockade in graft-versus-host disease prophylaxis-Reference-Cited by-同舟云学术

Clinical and immunologic impact of CCR5 blockade in graft-versus-host disease prophylaxis

Published:2017-02-16 Issue:7 Volume:129 Page:906-916
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Moy Ryan H.¹²,Huffman Austin P.¹³⁴,Richman Lee P.¹,Crisalli Lisa¹,Wang Ximi K.³⁴,Hoxie James A.¹,Mick Rosemarie¹⁵,Emerson Stephen G.⁶,Zhang Yi⁷,Vonderheide Robert H.¹,Porter David L.¹,Reshef Ran¹³⁴⁶

Affiliation:

1. Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

2. Department of Medicine, New York-Presbyterian Hospital–Weill Cornell Medical College, New York, NY;

3. Division of Hematology/Oncology and

4. Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY;

5. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

6. Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY; and

7. Department of Microbiology and Immunology, Temple University, Philadelphia, PA

Abstract

Key Points CCR5 blockade decreases peripheral T-cell activation, gut GVHD biomarkers, and acute GVHD incidence in allo-HSCT recipients. CXCR3-mediated lymphocyte trafficking may represent an important resistance mechanism to CCR5 blockade in GVHD prophylaxis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/7/906/1402182/blood735076.pdf

Reference41 articles.

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4. Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease;Murai;J Clin Invest,1999

5. Peyer’s patch is the essential site in initiating murine acute and lethal graft-versus-host reaction;Murai;Nat Immunol,2003

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