Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

Author:

Chiocca E. Antonio12ORCID,Yu John S.3ORCID,Lukas Rimas V.456,Solomon Isaac H.7,Ligon Keith L.7ORCID,Nakashima Hiroshi1,Triggs Daniel A.1,Reardon David A.2ORCID,Wen Patrick2,Stopa Brittany M.1ORCID,Naik Ajay1,Rudnick Jeremy3,Hu Jethro L.3ORCID,Kumthekar Priya45,Yamini Bakhtiar6ORCID,Buck Jill Y.8ORCID,Demars Nathan8ORCID,Barrett John A.8,Gelb Arnold B.8ORCID,Zhou John8,Lebel Francois8ORCID,Cooper Laurence J. N.89ORCID

Affiliation:

1. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

3. Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

4. Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

5. Lou and Jean Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

6. University of Chicago, Chicago, IL 60637, USA.

7. Division of Neuropathology, Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA.

8. Ziopharm Oncology, Inc., One First Avenue, Parris Building 34, Navy Yard Plaza, Charlestown, Boston, MA 02129, USA.

9. MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.

Abstract

An oral small molecule turns on the transcription of human interleukin-12, with biological effects in patients with recurrent high-grade gliomas.

Funder

National Cancer Institute

Ziopharm Oncology INc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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