Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

Author:

Ricklefs Franz L.12ORCID,Alayo Quazim1ORCID,Krenzlin Harald1ORCID,Mahmoud Ahmad B.13,Speranza Maria C.14,Nakashima Hiroshi1,Hayes Josie L.5ORCID,Lee Kyungheon6,Balaj Leonora7ORCID,Passaro Carmela1ORCID,Rooj Arun K.1ORCID,Krasemann Susanne8ORCID,Carter Bob S.7,Chen Clark C.9,Steed Tyler9ORCID,Treiber Jeffrey9ORCID,Rodig Scott10ORCID,Yang Katherine10ORCID,Nakano Ichiro11,Lee Hakho6ORCID,Weissleder Ralph6ORCID,Breakefield Xandra O.12ORCID,Godlewski Jakub1ORCID,Westphal Manfred2,Lamszus Katrin2,Freeman Gordon J.4ORCID,Bronisz Agnieszka1ORCID,Lawler Sean E.1ORCID,Chiocca E. Antonio1ORCID

Affiliation:

1. Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

3. College of Applied Medical Sciences, Taibah University, Madinah Munawwarah, Saudi Arabia.

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

5. School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.

6. Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

7. Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.

8. Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

9. Department of Neurosurgery, University of California, San Diego, La Jolla, CA 92121, USA.

10. Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA.

11. Comprehensive Cancer Center, University of Birmingham, Birmingham, AL 35294, USA.

12. Departments of Neurology and Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA.

Abstract

Glioblastoma can suppress immunity by using surface PD-L1 on extracellular vesicles to block T cell receptor–mediated T cell activation.

Funder

National Institutes of Health

National Cancer Institute

Deutsche Forschungsgemeinschaft

National Institute of Health

American-Italian Cancer Foundation Post-doctoral Research Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3