Long noncoding RNA SNHG12 integrates a DNA-PK–mediated DNA damage response and vascular senescence-Reference-Cited by-同舟云学术

Long noncoding RNA SNHG12 integrates a DNA-PK–mediated DNA damage response and vascular senescence

Published:2020-02-19 Issue:531 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Haemmig Stefan¹^ORCID,Yang Dafeng¹²^ORCID,Sun Xinghui¹^ORCID,Das Debapria¹,Ghaffari Siavash³,Molinaro Roberto¹⁴^ORCID,Chen Lei¹²,Deng Yihuan¹,Freeman Dan¹^ORCID,Moullan Norman⁵,Tesmenitsky Yevgenia¹,Wara A.K.M. Khyrul¹^ORCID,Simion Viorel¹^ORCID,Shvartz Eugenia¹,Lee James F.⁶^ORCID,Yang Tianlun²,Sukova Galina¹,Marto Jarrod A.⁶⁷⁸^ORCID,Stone Peter H.¹,Lee Warren L.³^ORCID,Auwerx Johan⁵^ORCID,Libby Peter¹^ORCID,Feinberg Mark W.¹

Affiliation:

1. Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Cardiology, Xiangya Hospital, Central South University, 0731 Changsha, Hunan, China.

3. Keenan Research Centre, St. Michael’s Hospital and Department of Biochemistry, University of Toronto, Toronto, ON M5B 1W8, Canada.

4. School of Pharmacy, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.

5. Laboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

6. The Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

7. Departments of Cancer Biology and Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

8. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Deficiency of lncRNA SNHG12 impairs DNA damage repair in the vessel wall and predisposes to vascular senescence and atherosclerosis.

Funder

National Institutes of Health

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference63 articles.

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2. Inflammation in Atherosclerosis

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4. Aging and Atherosclerosis

5. Cellular senescence: from physiology to pathology

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