BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis-Reference-Cited by-同舟云学术

BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis

Published:2020-05-06 Issue:542 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Brook Byron¹^ORCID,Harbeson Danny J.¹^ORCID,Shannon Casey P.²³^ORCID,Cai Bing⁴,He Daniel¹²³^ORCID,Ben-Othman Rym⁴,Francis Freddy¹^ORCID,Huang Joe⁴^ORCID,Varankovich Natallia⁴^ORCID,Liu Aaron¹^ORCID,Bao Winnie⁴^ORCID,Bjerregaard-Andersen Morten⁵⁶⁷,Schaltz-Buchholzer Frederik⁵⁶⁸^ORCID,Sanca Lilica⁵^ORCID,Golding Christian N.⁵⁶^ORCID,Larsen Kristina Lindberg⁵⁶^ORCID,Levy Ofer⁹¹⁰¹¹^ORCID,Kampmann Beate¹²¹³^ORCID,Tan Rusung¹⁴^ORCID,Charles Adrian¹⁴^ORCID,Wynn James L.¹⁵^ORCID,Shann Frank¹⁶^ORCID,Aaby Peter⁵,Benn Christine S.⁵⁶⁸^ORCID,Tebbutt Scott J.²³¹⁷^ORCID,Kollmann Tobias R.¹⁴¹⁸^ORCID,Amenyogbe Nelly¹¹⁸^ORCID,Lee Amy H.,Bennike Tue B.,Diray-Arce Joann,Idoko Olubukola,Pomat William S.,van Haren Simon,Cox Momoudou,Darboe Alansana,Falsafi Reza,Hinshaw Samuel H.,Ndure Jorjoh,Njie-Jobe Jainaba,Pettengill Matthew A.,Marchant Arnaud,Richmond Peter C.,Ford Rebecca,Saleu Gerard,Masiria Geraldine,Matlam John Paul,Kirarock Wendy,Roberts Elishia,Malek Mehrnoush,Sanchez-Schmitz Guzman,Singh Amrit,Angelidou Asimenia,Smolen Kinga K.,Brinkman Ryan R.,Ozonoff Al,Hancock Robert E.W.,van den Biggelaar Anita H.J.,Steen Hanno,Vo Diana,Kraft Ken,McEnaney Kerry,Vignolo Sofia,

Affiliation:

1. Department of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC V5Z 1M9, Canada.

2. PROOF Centre of Excellence, British Columbia, 10th floor, 1190 Hornby Street, Vancouver, BC V6Z 2K5, Canada.

3. UBC Centre for Heart Lung Innovation, St. Paul’s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.

4. Department of Pediatrics, University of British Columbia, and BC Children’s Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada.

5. Bandim Health Project, Indepth Network, Apartado 861, 1004 Bissau, Guinea-Bissau.

6. Research Center for Vitamins and Vaccines (CVIVA), Statens Serum Institut (SSI), Artillerivej 5, 2300 Copenhagen S, Denmark.

7. Department of Endocrinology, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark.

8. OPEN, Institute of Clinical Research and Danish Institute for Advanced Science, University of Southern Denmark, and Odense University Hospital, J.B. Winsløws Vej, 5000 Odense C, Denmark.

9. Precision Vaccines Program, Boston Children’s Hospital, Boston, MA 02115, USA.

10. Harvard Medical School, Boston, MA 02115, USA.

11. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

12. Vaccines and Immunity Theme, Medical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, The Gambia.

13. Vaccine Centre, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

14. Department of Pathology, Sidra Medicine and Weill Cornell Medicine, Doha, Qatar.

15. Department of Paediatrics and Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, P.O. Box 100296, Gainesville, FL 32610-0296, USA.

16. Department of Paediatrics, University of Melbourne, Melbourne, VIC 3052, Australia.

17. Department of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

18. Telethon Kids Institute, 100 Roberts Road, Subiaco, Western Australia 6008, Australia.

Abstract

Neonatal administration of BCG vaccine rapidly increases neutrophil production to reduce mortality from sepsis.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Medical Research Council

Danish National Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference118 articles.

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4. Every Newborn: progress, priorities, and potential beyond survival

5. Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: a systematic review and meta-analysis

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