Precision adjuvants for pediatric vaccines

Author:

Singh Anjali1ORCID,Boggiano César1ORCID,Yin Dwight E.1ORCID,Polakowski Laura1ORCID,Majji Sai P.2,Leitner Wolfgang W.3ORCID,Levy Ofer456ORCID,De Paris Kristina7ORCID

Affiliation:

1. Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.

2. Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20817, USA.

3. Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.

4. Precision Vaccines Program, Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115, USA.

5. Harvard Medical School, Boston, MA 02115, USA.

6. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

7. Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

Abstract

Elucidating optimal vaccine adjuvants for harnessing age-specific immune pathways to enhance magnitude, breadth, and durability of immunogenicity remains a key gap area in pediatric vaccine design. A better understanding of age-specific adjuvants will inform precision discovery and development of safe and effective vaccines for protecting children from preventable infectious diseases.

Publisher

American Association for the Advancement of Science (AAAS)

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