Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies-Reference-Cited by-同舟云学术

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Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies

Published:2020-03-11 Issue:534 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Santich Brian H.¹²^ORCID,Park Jeong A.²^ORCID,Tran Hoa²,Guo Hong-Fen²,Huse Morgan³^ORCID,Cheung Nai-Kong V.²^ORCID

Affiliation:

1. Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Abstract

T cell–bispecific antibody antitumor function is maximized through optimal interdomain spacing and dual cis-configurations.

Funder

Robert Steel Foundation

Enid A. Haupt Endowed Chair

Grayer Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference38 articles.

1. Factor VIII–Mimetic Function of Humanized Bispecific Antibody in Hemophilia A

2. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study

3. An anti–glypican 3/CD3 bispecific T cell–redirecting antibody for treatment of solid tumors

4. Preclinical Evaluation of Multistep Targeting of Diasialoganglioside GD2 Using an IgG-scFv Bispecific Antibody with High Affinity for GD2 and DOTA Metal Complex

5. The making of bispecific antibodies

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