An anti–glypican 3/CD3 bispecific T cell–redirecting antibody for treatment of solid tumors

Author:

Ishiguro Takahiro1ORCID,Sano Yuji2,Komatsu Shun-ichiro3,Kamata-Sakurai Mika3ORCID,Kaneko Akihisa3ORCID,Kinoshita Yasuko2,Shiraiwa Hirotake3,Azuma Yumiko2,Tsunenari Toshiaki2,Kayukawa Yoko2,Sonobe Yukiko2,Ono Natsuki3,Sakata Kiyoaki2,Fujii Toshihiko2,Miyazaki Yoko2,Noguchi Mizuho2,Endo Mika2,Harada Asako3,Frings Werner3ORCID,Fujii Etsuko2,Nanba Eitaro3ORCID,Narita Atsushi3,Sakamoto Akihisa3,Wakabayashi Tetsuya3ORCID,Konishi Hiroko3,Segawa Hiroaki3,Igawa Tomoyuki3ORCID,Tsushima Takashi2,Mutoh Hironori2ORCID,Nishito Yukari2ORCID,Takahashi Mina2,Stewart Lorraine4ORCID,ElGabry Ehab4,Kawabe Yoshiki23ORCID,Ishigai Masaki3,Chiba Shuichi3ORCID,Aoki Masahiro2ORCID,Hattori Kunihiro2,Nezu Junichi5ORCID

Affiliation:

1. Translational Clinical Research Division, Chugai Pharmaceutical Co., Ltd., 1-1 Nihonbashi-Muromachi 2-Chome Chuo-ku, Tokyo 103-8324, Japan.

2. Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.

3. Research Division, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan.

4. Companion Diagnostics Pharma Services, Ventana Medical Systems Inc., 1910 E Innovation Parkway, Tucson, AZ 85755, USA.

5. Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, Synapse 138623, Singapore.

Abstract

An anti–glypican 3/CD3 bispecific T cell–redirecting antibody (ERY974) is a promising therapeutic agent for solid tumors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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