A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management

Author:

Sun Xilin123ORCID,Xiao Zunyu1,Chen Gongyan4,Han Zhaoguo1,Liu Yang1,Zhang Chongqing1,Sun Yingying2,Song Yan1,Wang Kai12,Fang Fang2,Wang Xiance1,Lin Yanhong1,Xu Lili5,Shao Liming5,Li Jin6ORCID,Cheng Zhen3ORCID,Gambhir Sanjiv Sam3ORCID,Shen Baozhong12ORCID

Affiliation:

1. Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

2. TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150028, China.

3. Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

4. Department of Respiratory Medical Oncology, The Tumor Hospital Affiliated Harbin Medical University, Harbin, Heilongjiang 150049, China.

5. School of Pharmacy, Fudan University, Shanghai 201203, China.

6. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.

Abstract

18 F-MPG PET/CT enables noninvasive identification of NSCLC patients who may benefit from EGFR-TKI therapy and can be used to monitor treatment outcome.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Heilongjiang Province Foundation for Returned Overseas Chinese Scholars

Key Laboratory of Molecular Imaging Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference36 articles.

1. “Precision Medicine” Lister Hill National Center for Biomedical Communications U.S. National Library of Medicine National Institutes of Health Department of Health & Human Services published online 1 December 2016; https://ghr.nlm.nih.gov/primer/precisionmedicine/definition.

2. Moving toward precision medicine

3. Non–Small Cell Lung Cancer and Precision Medicine

4. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

5. Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

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