“AquaF” Building Blocks for Water-Compatible SN2 18F-Fluorination of Small-Molecule Radiotracers

Author:

Mou Zhaobiao12,Zhu Yiwei12,Zhang Lei3ORCID,Ma Mengting4,Li Zhongjing12,Guo Yiming12,Zheng Jiamei12,Zhao Zixiao12,Zhang Kaiqiang12,Chen Xiaoyuan5678ORCID,Li Zijing12ORCID

Affiliation:

1. State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen 361102, China

2. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen 361102, China

3. Tianjin Engineering Technology Center of Chemical Wastewater Source Reduction and Recycling, School of Science, Tianjin Chengjian University, Tianjin 300384, China

4. School of Medicine, Xiamen University, Xiamen 361102, China

5. Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore 119074, Singapore

6. Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore

7. Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore

8. Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore

Funder

National Medical Research Council

Ministry of Education - Singapore

National Research Foundation Singapore

National University of Singapore

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

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