Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers

Author:

Tsai Jonathan M.12ORCID,Sinha Rahul1ORCID,Seita Jun3ORCID,Fernhoff Nathaniel1,Christ Simon4ORCID,Koopmans Tim4ORCID,Krampitz Geoffrey W.15ORCID,McKenna Kelly M.1,Xing Liujing2,Sandholzer Michael4ORCID,Sales Jennifer Horatia4,Shoham Maia1,McCracken Melissa1,Joubert Lydia-Marie6ORCID,Gordon Sydney R.1,Poux Nicolas1,Wernig Gerlinde7ORCID,Norton Jeffrey A.5,Weissman Irving L.1278ORCID,Rinkevich Yuval4ORCID

Affiliation:

1. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. AI based Healthcare and Medical Data Analysis Standardization Unit, Medical Sciences Innovation Hub Program, RIKEN, Tokyo 103-0027, Japan.

4. Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

5. Department of General Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

6. Cell Sciences Imaging Facility, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA.

7. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

8. Ludwig Center for Cancer Stem Cell Biology and Medicine at Stanford University, Stanford, CA 94305, USA.

Abstract

Surgical adhesions in mice derived from hypoxia-responsive mesothelial cells can be targeted with anti-mesothelial antibodies.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

California Institute for Regenerative Medicine

Paul and Daisy Soros Fellowships for New Americans

Thomas and Stacey Siebel Foundation

Deutsche Forschungsgemeinschaft

Else-Kröner-Fresenius-Stiftung

Human Frontier Science Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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