Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen

Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen–specific CTLs

Published:2017-09-20 Issue:408 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Brown Michael C.¹^ORCID,Holl Eda K.²^ORCID,Boczkowski David²,Dobrikova Elena¹^ORCID,Mosaheb Mubeen¹³,Chandramohan Vidya⁴^ORCID,Bigner Darell D.⁴^ORCID,Gromeier Matthias¹³^ORCID,Nair Smita K.²⁴^ORCID

Affiliation:

1. Department of Neurosurgery, Duke University School of Medicine, Durham, NC 27710, USA.

2. Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

3. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.

4. Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

Abstract

PVSRIPO infection of tumors elicits antitumor immunity by damaging neoplastic cells and activating type I IFN responses in antigen-presenting cells.

Funder

U.S. Department of Defense

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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