Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia

Author:

Lertudomphonwanit Chatmanee12ORCID,Mourya Reena1,Fei Lin3ORCID,Zhang Yue3,Gutta Sridevi1,Yang Li14,Bove Kevin E.5,Shivakumar Pranavkumar1ORCID,Bezerra Jorge A.1ORCID

Affiliation:

1. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center and the Department of Pediatrics of the University of Cincinnati College of Medicine, Cincinnati, OH 45229–3031, USA.

2. Division of Gastroenterology and Hepatology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

3. Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center and the Department of Pediatrics of the University of Cincinnati College of Medicine, Cincinnati, OH 45229–3031, USA.

4. Division of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

5. Division of Pathology, Cincinnati Children’s Hospital Medical Center and the Department of Pediatrics of the University of Cincinnati College of Medicine, Cincinnati, OH 45229–3031, USA.

Abstract

Serum MMP-7 is released upon bile duct injury and has high diagnostic performance for biliary atresia.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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