Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia-Reference-Cited by-同舟云学术

Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia

Published:2024-08-01 Issue:2 Volume:327 Page:G267-G283
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Temple Haley¹,Donnelly Bryan¹,Mohanty Sujit K.²,Mowery Sarah¹,Poling Holly M.¹,Pasula Rajamouli¹,Hartman Stephen¹,Singh Akaljot¹,Mourya Reena³^ORCID,Bondoc Alexander¹,Meller Jaroslaw⁴⁵,Jegga Anil G.⁵^ORCID,Oyama Kei¹,McNeal Monica⁶⁷,Spearman Paul⁶⁷,Tiao Greg¹^ORCID

Affiliation:

1. Department of Pediatric and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States

2. Southeast Poultry Research Laboratory, United States National Poultry Research Center, United States Department of Agriculture, Athens, Georgia, United States

3. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States

4. Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, Ohio, United States

5. Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States

6. Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States

7. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States

Abstract

In this study, we have determined that the presence of the “SRL” peptide on RRV alters its method of endocytosis and intracellular trafficking through viral binding to heat shock cognate 70 protein. This initiates an inflammatory pathway that stimulates the release of cytokines associated with biliary damage and obstruction.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | National Institutes of Health

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00308.2023

Reference52 articles.

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2. Grade IV Fibrosis Interferes in Biliary Drainage After Kasai Procedure

3. The Pathogenesis of Biliary Atresia: Evidence for a Virus-Induced Autoimmune Disease

4. Group A Rotaviruses Produce Extrahepatic Biliary Obstruction in Orally Inoculated Newborn Mice