Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

Author:

Zhang Liang1ORCID,Yao Yixin1ORCID,Zhang Shaojun2ORCID,Liu Yang1ORCID,Guo Hui1,Ahmed Makhdum1ORCID,Bell Taylor1ORCID,Zhang Hui1ORCID,Han Guangchun2ORCID,Lorence Elizabeth1ORCID,Badillo Maria1,Zhou Shouhao3ORCID,Sun Yuting4,Di Francesco M. Emilia4ORCID,Feng Ningping4,Haun Randy5,Lan Renny6ORCID,Mackintosh Samuel G.6,Mao Xizeng2,Song Xingzhi2,Zhang Jianhua2ORCID,Pham Lan V.7,Lorenzi Philip L.8ORCID,Marszalek Joseph4ORCID,Heffernan Tim4ORCID,Draetta Giulio24ORCID,Jones Philip4ORCID,Futreal Andrew2ORCID,Nomie Krystle1,Wang Linghua2ORCID,Wang Michael19ORCID

Affiliation:

1. Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

3. Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

4. Institute for Applied Cancer Science and Center for Co-Clinical Trials, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

5. Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

6. Department of Biochemistry and Molecular Biology and Proteomics Core Facility, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

7. Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

8. Proteomics and Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

9. Department of Stem Cell Transplantation and Cellular Therapy, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Targeting oxidative phosphorylation overcomes ibrutinib resistance in mantle cell lymphoma.

Funder

National Institutes of Health

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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