Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition-Reference-Cited by-同舟云学术

Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition

Published:2019-05-15 Issue:492 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Esler William P.¹^ORCID,Tesz Gregory J.¹^ORCID,Hellerstein Marc K.²³,Beysen Carine²,Sivamani Raja⁴^ORCID,Turner Scott M.²,Watkins Steven M.⁵,Amor Paul A.¹,Carvajal-Gonzalez Santos¹^ORCID,Geoly Frank J.⁶^ORCID,Biddle Kathleen E.⁶,Purkal Julie J.¹^ORCID,Fitch Mark³^ORCID,Buckeridge Clare¹,Silvia Annette M.¹^ORCID,Griffith David A.¹,Gorgoglione Matthew¹,Hassoun Lauren⁴,Bosanac Suzana S.⁴^ORCID,Vera Nicholas B.¹^ORCID,Rolph Timothy P.¹^ORCID,Pfefferkorn Jeffrey A.¹,Sonnenberg Gabriele E.¹

Affiliation:

1. Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer Global Research and Development, Cambridge, MA 02139, USA.

2. KineMed Inc., Emeryville, CA 94608, USA.

3. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.

4. Department of Dermatology, School of Medicine, University of California, Davis, Davis, CA 95816, USA.

5. Verso Biosciences, Davis, CA 95618, USA.

6. Drug Safety Research and Development, Pfizer Global Research and Development, Groton, CT 06340, USA.

Abstract

De novo lipogenesis is essential for human sebum production, and increased lipogenic flux accounts for excessive sebum production in acne vulgaris.

Funder

Pfizer

Pfizer Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference59 articles.

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3. Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition

4. Acetyl-coenzyme A carboxylases: Versatile targets for drug discovery

5. Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

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