Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia

Author:

Taylor Alison M.123ORCID,Macari Elizabeth R.123,Chan Iris T.12ORCID,Blair Megan C.12,Doulatov Sergei123ORCID,Vo Linda T.123ORCID,Raiser David M.234,Siva Kavitha5ORCID,Basak Anindita236ORCID,Pirouz Mehdi123ORCID,Shah Arish N.7ORCID,McGrath Katherine12ORCID,Humphries Jessica M.12,Stillman Emma12ORCID,Alter Blanche P.8ORCID,Calo Eliezer7ORCID,Gregory Richard I.123ORCID,Sankaran Vijay G.236ORCID,Flygare Johan5ORCID,Ebert Benjamin L.236ORCID,Zhou Yi12ORCID,Daley George Q.123ORCID,Zon Leonard I.123910ORCID

Affiliation:

1. Stem Cell Program, Boston Children’s Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.

2. Division of Hematology/Oncology, Boston Children’s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.

3. Harvard Medical School, Boston, MA 02115, USA.

4. Division of Hematology, Brigham and Women’s Hospital, Boston, MA 02115, USA.

5. Stem Cell Center, Lund University, Lund 22184, Sweden.

6. Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.

7. MIT Department of Biology and David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.

8. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20850, USA.

9. Howard Hughes Medical Institute, Boston, MA 02115, USA.

10. Stem Cell and Regenerative Biology Department, Harvard University, Boston, MA 02115, USA.

Abstract

Calmodulin inhibitors rescue erythropoiesis and p53-dependent phenotypes of Diamond-Blackfan anemia.

Funder

National Science Foundation

National Heart, Lung, and Blood Institute

Henry and Marilyn Taub Foundation

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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