The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer

Author:

Vollmer Tino123ORCID,Schlickeiser Stephan12ORCID,Amini Leila123ORCID,Schulenberg Sarah2ORCID,Wendering Desiree J.123,Banday Viqar45ORCID,Jurisch Anke123ORCID,Noster Rebecca2ORCID,Kunkel Desiree2ORCID,Brindle Nicola R.2ORCID,Savidis Ioannis2,Akyüz Levent12ORCID,Hecht Jochen67,Stervbo Ulrik8ORCID,Roch Toralf28ORCID,Babel Nina28,Reinke Petra23ORCID,Winqvist Ola9,Sherif Amir4ORCID,Volk Hans-Dieter12,Schmueck-Henneresse Michael123ORCID

Affiliation:

1. Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, D-13353 Berlin, Germany.

2. Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité – Universitätsmedizin Berlin, D-13353 Berlin, Germany.

3. Berlin Center for Advanced Therapies (BeCAT), Charité – Universitätsmedizin Berlin, D-13353 Berlin, Germany.

4. Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, 901 85 Umea, Sweden.

5. Department of Clinical Microbiology, Immunology, Umea University, 901 85 Umea, Sweden.

6. Centre for Genomic Regulation, Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.

7. Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.

8. Center for Translational Medicine, Medical Clinic I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, D-44623 Herne, Germany.

9. Department of Clinical Immunology, Karolinska University Hospital, 17 176 Stockholm, Sweden.

Abstract

Activity of the CXCR3alt-CXCL11 chemokine system in CD8 + stem-like T cells predicts chemotherapy response in patients with bladder cancer.

Funder

Deutsche Forschungsgemeinschaft

Einstein Stiftung Berlin

Bundesministerium für Bildung, Wissenschaft und Forschung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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