Genetic prion disease–related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM-Reference-Cited by-同舟云学术

Genetic prion disease–related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

Published:2021-09-10 Issue:37 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wang Li-Qiang¹^ORCID,Zhao Kun²³^ORCID,Yuan Han-Ye¹^ORCID,Li Xiang-Ning¹,Dang Hai-Bin¹,Ma Yeyang²³,Wang Qiang⁴^ORCID,Wang Chen⁵,Sun Yunpeng²³^ORCID,Chen Jie¹,Li Dan⁶^ORCID,Zhang Delin⁴^ORCID,Yin Ping⁴^ORCID,Liu Cong²^ORCID,Liang Yi¹^ORCID

Affiliation:

1. Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.

2. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.

3. University of Chinese Academy of Sciences, Beijing 100049, China.

4. National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research, Huazhong Agricultural University, Wuhan 430070, China.

5. Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.

6. Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China.

Abstract

The cryo-EM structure of genetic CJD mutation E196K fibril reveals a novel fibril polymorph of human prion protein.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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