Author:
Asarnow Daniel,Becker Vada A.,Bobe Daija,Dubbledam Charlie,Johnston Jake D.,Kopylov Mykhailo,Lavoie Nathalie R.,Li Qiuye,Mattingly Jacob M.,Mendez Joshua H.,Paraan Mohammadreza,Turner Jack,Upadhye Viraj,Walsh Richard M.,Gupta Meghna,Eng Edward T.
Abstract
With the increasing spread of infectious diseases worldwide, there is an urgent need for novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) techniques, particularly electron tomography (cryo-ET), have revolutionized the field of infectious disease research by enabling multiscale observation of biological structures in a near-native state. This review highlights the recent advances in infectious disease research using cryo-ET and discusses the potential of this structural biology technique to help discover mechanisms of infection in native environments and guiding in the right direction for future drug discovery.