Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide-Reference-Cited by-同舟云学术

Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide

Published:2018-01-05 Issue:1 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Guan Yijia¹²,Du Zhi¹²,Gao Nan¹,Cao Yue¹,Wang Xiaohui¹,Scott Peter³^ORCID,Song Hualong³^ORCID,Ren Jinsong¹,Qu Xiaogang¹^ORCID

Affiliation:

1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.

2. University of Chinese Academy of Sciences, Beijing 100039, China.

3. Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.

Abstract

Metallosupramolecular complexes can enantioselectively target the central hydrophobic α/β discordant stretch of Aβ.

Funder

University of Warwick

NSFC

973 Project

CAS

China Scholarships Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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