Noninvasive monitoring of hepatic glutathione depletion through fluorescence imaging and blood testing

Author:

Jiang Xingya1ORCID,Zhou Qinhan1ORCID,Du Bujie1ORCID,Li Siqing1,Huang Yingyu1,Chi Zhikai2,Lee William M.3ORCID,Yu Mengxiao1,Zheng Jie14ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA.

2. Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8887, USA.

3. Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8887, USA.

4. Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8887, USA.

Abstract

Hepatic glutathione depletion, a crucial pathophysiological event, can now be readily monitored for early disease remedy.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Welch Foundation

Cancer Prevention and Research Institute of Texas

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. Glutathione defense mechanism in liver injury: Insights from animal models

2. GLUTATHIONE

3. The Regulation of Hepatic Glutathione

4. The importance and regulation of hepatic glutathione;Kaplowitz N.;Yale J. Biol. Med.,1981

5. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione;Mitchell J.;J. Pharmacol. Exp. Ther.,1973

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