Mesenchymal growth hormone receptor deficiency leads to failure of alveolar progenitor cell function and severe pulmonary fibrosis-Reference-Cited by-同舟云学术

Mesenchymal growth hormone receptor deficiency leads to failure of alveolar progenitor cell function and severe pulmonary fibrosis

Published:2021-06-11 Issue:24 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Xie Ting¹^ORCID,Kulur Vrishika¹^ORCID,Liu Ningshan¹,Deng Nan²^ORCID,Wang Yizhou³,Rowan Simon Coyle¹^ORCID,Yao Changfu¹^ORCID,Huang Guanling¹,Liu Xue¹,Taghavifar Forough¹,Liang Jiurong¹^ORCID,Hogaboam Cory¹^ORCID,Stripp Barry¹^ORCID,Chen Peter¹^ORCID,Jiang Dianhua¹^ORCID,Noble Paul W.¹^ORCID

Affiliation:

1. Department of Medicine, Division of Pulmonary and Critical Care Medicine, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

2. Biostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

3. Genomics Core, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Abstract

Mesenchymal vesicular GHR supports alveolar epithelial progenitor cell renewal and limits lung fibrosis.

Funder

National Institutes of Health

American Heart Association

Marie Skłodowska-Curie grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.

1. Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis

2. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy

3. Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6

4. Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung

5. Lung Stem and Progenitor Cells in Tissue Homeostasis and Disease

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