Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis

Author:

Cao Zhongwei12ORCID,Ye Tinghong1ORCID,Sun Yue1ORCID,Ji Gaili1ORCID,Shido Koji2ORCID,Chen Yutian1ORCID,Luo Lin13ORCID,Na Feifei13ORCID,Li Xiaoyan1ORCID,Huang Zhen1ORCID,Ko Jane L.4,Mittal Vivek5,Qiao Lina1,Chen Chong13,Martinez Fernando J.6,Rafii Shahin2,Ding Bi-Sen12ORCID

Affiliation:

1. Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.

2. Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

3. West China Hospital, Sichuan University, China.

4. Department of Biological Sciences, Seton Hall University, South Orange, NJ 07079, USA.

5. Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, USA.

6. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

Abstract

Targeted gene delivery and enzyme inhibition in vascular and perivascular cells promote engraftment of transplanted parenchymal cells for lung and liver repair.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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