Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway-Reference-Cited by-同舟云学术

Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway

Published:2020-04-17 Issue:16 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Lim Jisun¹²^ORCID,Heo Jinbeom¹²^ORCID,Ju Hyein¹²^ORCID,Shin Ji-Woong³⁴^ORCID,Kim YongHwan¹²⁴^ORCID,Lee Seungun¹²^ORCID,Yu Hwan Yeul¹²^ORCID,Ryu Chae-Min¹²^ORCID,Yun HongDuck¹²^ORCID,Song Sujin¹²^ORCID,Hong Ki-Sung⁵^ORCID,Chung Hyung-Min⁵^ORCID,Kim Hwa-Ryeon⁶^ORCID,Roe Jae-Seok⁶,Choi Kihang⁷,Kim In-Gyu³^ORCID,Jeong Eui Man³^ORCID,Shin Dong-Myung¹²^ORCID

Affiliation:

1. Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

2. Department of Physiology, University of Ulsan College of Medicine, Seoul 05505, Korea.

3. Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.

4. Biomedical Research Institute, Cell2in Co. Ltd., Seoul 03080, Korea.

5. Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 05029, Korea.

6. Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.

7. Department of Chemistry, Korea University, Seoul 02841, Korea.

Abstract

Real-time monitoring of GSH dynamics demonstrates the functional roles of CREB1-NRF2 pathway in MSC therapeutic potency.

Funder

Ministry of Education

National Research Foundation of Korea

Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. Novel targets in the treatment of chronic graft-versus-host disease

2. Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

3. Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets

4. Cytokine mediators of chronic graft-versus-host disease

5. Influence of immunosuppressive treatment on risk of recurrent malignancy after allogeneic hematopoietic cell transplantation

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