Superhuman cell death detection with biomarker-optimized neural networks

Author:

Linsley Jeremy W.1ORCID,Linsley Drew A.23ORCID,Lamstein Josh1ORCID,Ryan Gennadi1ORCID,Shah Kevan1ORCID,Castello Nicholas A.1,Oza Viral1ORCID,Kalra Jaslin1ORCID,Wang Shijie1ORCID,Tokuno Zachary1ORCID,Javaherian Ashkan1ORCID,Serre Thomas23ORCID,Finkbeiner Steven14567ORCID

Affiliation:

1. Center for Systems and Therapeutics, Gladstone Institutes, San Francisco, CA 94158, USA.

2. Robert J. & Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI 02912, USA.

3. Department of Cognitive, Linguistic & Psychological Sciences, Brown University, Providence, RI 02912, USA.

4. Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes, San Francisco, CA 94158, USA.

5. Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.

6. Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.

7. Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

High-throughput microscopy has outpaced analysis; biomarker-optimized CNNs are a generalizable, fast, and interpretable solution.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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