Superhuman cell death detection with biomarker-optimized neural networks-Reference-Cited by-同舟云学术

Superhuman cell death detection with biomarker-optimized neural networks

Published:2021-12-10 Issue:50 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Linsley Jeremy W.¹^ORCID,Linsley Drew A.²³^ORCID,Lamstein Josh¹^ORCID,Ryan Gennadi¹^ORCID,Shah Kevan¹^ORCID,Castello Nicholas A.¹,Oza Viral¹^ORCID,Kalra Jaslin¹^ORCID,Wang Shijie¹^ORCID,Tokuno Zachary¹^ORCID,Javaherian Ashkan¹^ORCID,Serre Thomas²³^ORCID,Finkbeiner Steven¹⁴⁵⁶⁷^ORCID

Affiliation:

1. Center for Systems and Therapeutics, Gladstone Institutes, San Francisco, CA 94158, USA.

2. Robert J. & Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI 02912, USA.

3. Department of Cognitive, Linguistic & Psychological Sciences, Brown University, Providence, RI 02912, USA.

4. Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes, San Francisco, CA 94158, USA.

5. Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.

6. Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.

7. Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

High-throughput microscopy has outpaced analysis; biomarker-optimized CNNs are a generalizable, fast, and interpretable solution.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

2. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

3. Quantitative Relationships between Huntingtin Levels, Polyglutamine Length, Inclusion Body Formation, and Neuronal Death Provide Novel Insight into Huntington's Disease Molecular Pathogenesis

4. A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

5. Extracting Rich Information from Images

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