Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

Author:

Mudd Philip A.1ORCID,Crawford Jeremy Chase2ORCID,Turner Jackson S.3ORCID,Souquette Aisha2ORCID,Reynolds Daniel4,Bender Diane5ORCID,Bosanquet James P.6,Anand Nitin J.6,Striker David A.6,Martin R. Scott6,Boon Adrianus C. M.4ORCID,House Stacey L.1,Remy Kenneth E.478,Hotchkiss Richard S.489,Presti Rachel M.4ORCID,O’Halloran Jane A.4,Powderly William G.4ORCID,Thomas Paul G.2ORCID,Ellebedy Ali H.345ORCID

Affiliation:

1. Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO, USA.

2. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA.

3. Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.

4. Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.

5. Bursky Center for Human Immunology and Immunotherapy Program, Washington University School of Medicine, Saint Louis, MO, USA.

6. Department of Critical Care, Missouri Baptist Medical Center, Saint Louis, MO, USA.

7. Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO, USA.

8. Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.

9. Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.

Abstract

Immunologic evaluation shows that most COVID-19 patients exhibit targeted immunosuppression compared to patients with influenza.

Funder

National Institute of Allergy and Infectious Diseases

National Center for Advancing Translational Sciences

Foundation for Barnes-Jewish Hospital

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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