Cryo-EM structure of the human heteromeric amino acid transporter b 0,+ AT-rBAT-Reference-Cited by-同舟云学术

Cryo-EM structure of the human heteromeric amino acid transporter b 0,+ AT-rBAT

Published:2020-04-17 Issue:16 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yan Renhong¹^ORCID,Li Yaning²,Shi Yi¹^ORCID,Zhou Jiayao²^ORCID,Lei Jianlin³^ORCID,Huang Jing¹^ORCID,Zhou Qiang¹^ORCID

Affiliation:

1. Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.

2. Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

3. Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Abstract

Cryo-EM structures of the b 0,+ AT-rBAT complex are revealed, providing clues for the substrate recognition and transport mechanism.

Funder

National Natural Science Foundation of China

Zhejiang Provincial Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference58 articles.

1. Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond

2. The SLC3 and SLC7 families of amino acid transporters