The H3K36me2 writer-reader dependency in H3K27M-DIPG-Reference-Cited by-同舟云学术

The H3K36me2 writer-reader dependency in H3K27M-DIPG

Published:2021-07-16 Issue:29 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yu Jia-Ray¹²^ORCID,LeRoy Gary¹²^ORCID,Bready Devin³^ORCID,Frenster Joshua D.³^ORCID,Saldaña-Meyer Ricardo¹²,Jin Ying⁴,Descostes Nicolas¹²⁵,Stafford James M.¹²⁶^ORCID,Placantonakis Dimitris G.³⁷⁸⁹¹⁰^ORCID,Reinberg Danny¹²^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.

2. Howard Hughes Medical Institute, New York University Grossman School of Medicine, New York, NY, USA.

3. Department of Neurosurgery, New York University Grossman School of Medicine, New York, NY, USA.

4. Shared Bioinformatics Core Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

5. EMBL Rome, Adriano Buzzati-Traverso Campus, Rome, Italy.

6. Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington, VT, USA.

7. Kimmel Center for Stem Cell Biology, New York University Grossman School of Medicine, New York, NY, USA.

8. Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.

9. Brain and Spine Tumor Center, New York University Grossman School of Medicine, New York, NY, USA.

10. Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.

Abstract

The H3K36me2 histone modification pathway is an acquired dependency in H3K27M mutant diffuse intrinsic pontine glioma (DIPG).

Funder

Howard Hughes Medical Institute

National Institute on Alcohol Abuse and Alcoholism

American Cancer Society

National Cancer Institute

National Institute of Neurological Disorders and Stroke

National Institute of Biomedical Imaging and Bioengineering

Directorate for Geosciences

Simons Foundation

Alex’s Lemonade Stand Foundation for Childhood Cancer

New York State Stem Cell Science

DFG

Making Headway Foundation St. Baldrick’s Research Grant

Hyundai Hope on Wheels Research Grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference50 articles.

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2. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

3. Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

4. Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria

5. Survival rates and prognostic predictors of high grade brain stem gliomas in childhood: a systematic review and meta-analysis

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