Author:
Honer Madison A.,Ferman Benjamin I.,Gray Zach H.,Bondarenko Elena A.,Whetstine Johnathan R.
Abstract
The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed light on previously underappreciated biological mechanisms that promote diseases. With these insights, novel biomarkers and innovative combination therapies can be used to address challenging and difficult to treat disease states. This review highlights key mechanisms that epigenetic writers, erasers, readers, and remodelers control, as well as their connection with disease states and recent advances in associated epigenetic therapies.
Funder
National Institutes of Health/National Cancer Institue Cancer Center
Publisher
Cold Spring Harbor Laboratory