Altered 3D chromatin structure permits inversional recombination at the IgH locus-Reference-Cited by-同舟云学术

Altered 3D chromatin structure permits inversional recombination at the IgH locus

Published:2020-08-14 Issue:33 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Qiu Xiang¹^ORCID,Ma Fei¹^ORCID,Zhao Mingming¹,Cao Yaqiang²^ORCID,Shipp Lillian¹^ORCID,Liu Angela¹^ORCID,Dutta Arun¹^ORCID,Singh Amit¹^ORCID,Braikia Fatima Zohra¹,De Supriyo³^ORCID,Wood William H.³,Becker Kevin G.³^ORCID,Zhou Weiqiang⁴^ORCID,Ji Hongkai⁴^ORCID,Zhao Keji²,Atchison Michael L.⁵,Sen Ranjan¹^ORCID

Affiliation:

1. Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.

2. Laboratory of Epigenome Biology, Systems Biology Center, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.

3. Laboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD 21224, USA.

4. Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA.

5. Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Abstract

Different mechanisms govern the first and second steps of IgH gene recombination.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference55 articles.

1. Regulation and Evolution of the RAG Recombinase

2. RAG Chromatin Scanning During V(D)J Recombination and Chromatin Loop Extrusion are Related Processes

3. Chromatin Interactions in the Control of Immunoglobulin Heavy Chain Gene Assembly

4. Regulation of IgH Gene Assembly: Role of the Intronic Enhancer and 5′DQ52 Region in Targeting DHJH Recombination

5. Repeat Organization and Epigenetic Regulation of the DH-Cμ Domain of the Immunoglobulin Heavy-Chain Gene Locus

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