Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway-Reference-Cited by-同舟云学术

Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway

Published:2019-10-04 Issue:10 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Xu Mafei¹^ORCID,Qin Jun²^ORCID,Wang Leiming¹,Lee Hui-Ju³,Kao Chung-Yang¹,Liu Dan⁴,Songyang Zhou⁴⁵⁶,Chen Junjie⁷,Tsai Ming-Jer¹⁸^ORCID,Tsai Sophia Y.¹⁸^ORCID

Affiliation:

1. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

2. CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

3. Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX, USA.

4. Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.

5. School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.

6. Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

7. Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

8. Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.

Abstract

We report a novel pathway where FANCD2 binds to nuclear receptors, COUP-TFII/TR4, to promote alternative lengthening of telomeres.

Funder

National Institutes of Health

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Welch Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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