TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles-Reference-Cited by-同舟云学术

TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles

Published:2020-11-13 Issue:46 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Chen Cheng-Chang¹^ORCID,Krogsaeter Einar²^ORCID,Butz Elisabeth S.³,Li Yanfen¹^ORCID,Puertollano Rosa⁴,Wahl-Schott Christian⁵,Biel Martin¹^ORCID,Grimm Christian²^ORCID

Affiliation:

1. Department of Pharmacy–Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.

2. Walther Straub Institute of Pharmacology and Toxicology Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.

3. Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

4. Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.

5. Institute for Neurophysiology, Hannover Medical School, Hannover, Germany.

Abstract

Protein trafficking is mediated by tubulation/vesiculation of endosomes and is regulated by osmo/mechanosensitive TRPML2.

Funder

Deutsche Forschungsgemeinschaft

German Research Foundation

University of Pennsylvania Orphan Disease Center and the Mucolipidosis IV Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

1. Sphingolipid lysosomal storage disorders

2. From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease

3. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

4. Lysosomal Physiology

5. Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance

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