Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance

Author:

Freeman Spencer A.1ORCID,Uderhardt Stefan23ORCID,Saric Amra4ORCID,Collins Richard F.1,Buckley Catherine M.15ORCID,Mylvaganam Sivakami1,Boroumand Parastoo1ORCID,Plumb Jonathan1ORCID,Germain Ronald N.2,Ren Dejian6,Grinstein Sergio17ORCID

Affiliation:

1. Program in Cell Biology, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, ON, Canada.

2. Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

3. Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen and Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

4. Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

5. Institute of Microbiology and Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK.

6. Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.

7. Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada.

Abstract

Ion fluxes resolve organellar volume Animal cells continuously sample the surrounding medium, a feature accentuated in immune cells. Sampling is accomplished by trapping external medium into membrane-bound vesicles or vacuoles. These structures are promptly resolved, thus avoiding accumulation of endomembranes and volume expansion. In a variety of cultured cells, Freeman et al. found that this resolution entails conversion of spherical vacuoles into thin tubules, a process that involves marked changes in surface-to-volume ratio (see the Perspective by King and Smythe). Shrinkage of membrane-bound structures is driven by ion fluxes and subsequent osmotic transfer of water. Shriveled vacuoles attract curvature-sensing proteins that promote the extension of fine tubules. Ion channels thereby control membrane remodeling, enabling receptor recycling and proper routing of cellular cargo. Science , this issue p. 301 ; see also p. 246

Funder

National Institutes of Health

Wellcome

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Cited by 121 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3