A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair-Reference-Cited by-同舟云学术

A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair

Published:2019-03 Issue:3 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Li Weizhe¹^ORCID,Wang Hong-Yan¹^ORCID,Zhao Xiaolu¹,Duan Hongguo¹,Cheng Binghua²,Liu Yafei¹,Zhao Mengjie¹,Shu Wenjie¹,Mei Yuchao¹,Wen Zengqi³,Tang Mingliang¹,Guo Lin⁴^ORCID,Li Guohong³,Chen Qiang²^ORCID,Liu Xiaoqi⁵⁶,Du Hai-Ning¹^ORCID

Affiliation:

1. Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.

2. Medical Research Institute, School of Medicine, Wuhan University, Wuhan 430071, China.

3. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences ,Beijing 100101, China.

4. State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.

5. Department of Biochemistry, Purdue University, West Lafayette, IN, USA.

6. Center for Cancer Research, Purdue University, West Lafayette, IN, USA.

Abstract

Two types of small-group modifications on Plk1 control its activity and its cellular functions.

Funder

National Natural Science Foundation of China

Major State Basic Research Development Program of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary