Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins-Reference-Cited by-同舟云学术

Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins

Published:2019-06-07 Issue:6 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yen Tien-Jui¹^ORCID,Lolicato Marco¹^ORCID,Thomas-Tran Rhiannon²,Du Bois J.²^ORCID,Minor Daniel L.¹³⁴⁵⁶^ORCID

Affiliation:

1. Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

3. Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.

4. California Institute for Quantitative Biomedical Research, San Francisco, CA 94158, USA.

5. Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.

6. Molecular Biophysics and Integrated Bio-imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Abstract

Bullfrog saxiphilin:STX complex defines a toxin “molecular sponge” blueprint for STX recognition and toxin resistance.

Funder

National Science Foundation

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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