Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism-Reference-Cited by-同舟云学术

Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism

Published:2021-01-29 Issue:5 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Deluigi Mattia¹^ORCID,Klipp Alexander¹^ORCID,Klenk Christoph¹^ORCID,Merklinger Lisa¹^ORCID,Eberle Stefanie A.¹,Morstein Lena¹^ORCID,Heine Philipp¹^ORCID,Mittl Peer R. E.¹,Ernst Patrick¹^ORCID,Kamenecka Theodore M.²,He Yuanjun²^ORCID,Vacca Santiago¹^ORCID,Egloff Pascal¹,Honegger Annemarie¹^ORCID,Plückthun Andreas¹^ORCID

Affiliation:

1. Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

2. Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #A2A, Jupiter, FL 33458, USA.

Abstract

Crystal structures of NTSR1 bound to agonists, inverse agonists, and in the apo state enabled by a novel fusion to DARPin D12.

Funder

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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