Loss of UCHL1 rescues the defects related to Parkinson’s disease by suppressing glycolysis-Reference-Cited by-同舟云学术

Loss of UCHL1 rescues the defects related to Parkinson’s disease by suppressing glycolysis

Published:2021-07-09 Issue:28 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ham Su Jin¹²³^ORCID,Lee Daewon²³^ORCID,Xu Wen Jun⁴,Cho Eunjoo²^ORCID,Choi Sekyu²^ORCID,Min Soohong²³^ORCID,Park Sunghyouk⁴,Chung Jongkyeong¹²³^ORCID

Affiliation:

1. Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Seoul 08826, Republic of Korea.

2. Institute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Republic of Korea.

3. School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea.

4. Department of Manufacturing Pharmacy, Natural Product Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

Abstract

Loss of UCHL1 activates an energy-dependent mitophagy via pyruvate kinase, which relieves Parkinson’s disease symptoms.

Funder

National Research Foundation of Korea

Ministry of Science and ICT, South Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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