Selective neuronal vulnerability in Parkinson disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn.2016.178.pdf
Reference173 articles.
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2. Hornykiewicz, O. Dopamine miracle: from brain homogenate to dopamine replacement. Mov. Disord. 17, 501–508 (2002).
3. Goedert, M., Spillantini, M. G., Del Tredici, K. & Braak, H. 100 years of Lewy pathology. Nat. Rev. Neurol. 9, 13–24 (2012).
4. Dijkstra, A. A. et al. Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease. Mov. Disord. 29, 1244–1251 (2014). This paper describes a negative correlation between neuronal density and local α-syn burden in the SN of patients with PD and shows that the severity of neurodegeneration and local burden of α-syn pathological conditions are closely coupled during disease progression.
5. Hawkes, C. H., Del Tredici, K. & Braak, H. Parkinson's disease: a dual-hit hypothesis. Neuropathol. Appl. Neurobiol. 33, 599–614 (2007).
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