The inositol pyrophosphate 5-InsP 7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α

Author:

Chin Alfred C.1ORCID,Gao Zhe23ORCID,Riley Andrew M.4ORCID,Furkert David5ORCID,Wittwer Christopher6ORCID,Dutta Amit6,Rojas Tomas1ORCID,Semenza Evan R.1ORCID,Felder Robin A.7ORCID,Pluznick Jennifer L.8ORCID,Jessen Henning J.6ORCID,Fiedler Dorothea5,Potter Barry V. L.4ORCID,Snyder Solomon H.1910ORCID,Fu Chenglai23ORCID

Affiliation:

1. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

2. Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.

3. Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.

4. Medicinal Chemistry and Drug Discovery, Department of Pharmacology, University of Oxford, Oxford, UK.

5. Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.

6. Institute of Organic Chemistry and CIBSS—Centre for Integrative Biological Signalling Studies, University of Freiburg, D-79104 Freiburg, Germany.

7. Department of Pathology, University of Virginia, Charlottesville, VA, USA.

8. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

9. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

10. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

5-InsP 7 is an endogenous negative regulator of Na + /K + -ATPase.

Funder

National Natural Science Foundation of China

United States Public Health Service

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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