Ca 2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG-Reference-Cited by-同舟云学术

Ca 2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

Published:2021-03-26 Issue:13 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Balestra Aurélia C.¹^ORCID,Koussis Konstantinos²^ORCID,Klages Natacha¹,Howell Steven A.³,Flynn Helen R.³^ORCID,Bantscheff Marcus⁴^ORCID,Pasquarello Carla⁵,Perrin Abigail J.²^ORCID,Brusini Lorenzo¹^ORCID,Arboit Patrizia⁵,Sanz Olalla⁶^ORCID,Castaño Laura Peces-Barba²^ORCID,Withers-Martinez Chrislaine²^ORCID,Hainard Alexandre⁵,Ghidelli-Disse Sonja⁴^ORCID,Snijders Ambrosius P.³^ORCID,Baker David A.⁷^ORCID,Blackman Michael J.²⁷^ORCID,Brochet Mathieu¹^ORCID

Affiliation:

1. Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.

2. Malaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

3. Mass Spectrometry Proteomics Platform, The Francis Crick Institute, London, UK.

4. Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, 69117 Heidelberg, Germany.

5. Proteomics Core Facility, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.

6. Diseases of the Developing World Global Health Pharma Unit, GlaxoSmithKline, 28760 Tres Cantos, Spain.

7. Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.

Abstract

A membrane protein interacts with PKG and regulates calcium signals at multiple lifecycle stages in malaria parasites.

Funder

Novartis Foundation

Wellcome

Medical Research Council

Swiss National Science Foundation

Fondation privée des Hôpitaux Universitaires de Genève

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference77 articles.

1. WHO World malaria report (2019).

2. Cyclic nucleotide signalling in malaria parasites

3. Calcium signalling in malaria parasites

4. The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

5. Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function

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