Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer

Author:

Yan Kezhi12ORCID,Rousseau Justine3,Machol Keren45ORCID,Cross Laura A.6,Agre Katherine E.7,Gibson Cynthia Forster8,Goverde Anne9ORCID,Engleman Kendra L.6,Verdin Hannah10ORCID,De Baere Elfride10,Potocki Lorraine45,Zhou Dihong6,Cadieux-Dion Maxime6ORCID,Bellus Gary A.11,Wagner Monisa D.12,Hale Rebecca J.7,Esber Natacha13ORCID,Riley Alan F.14ORCID,Solomon Benjamin D.15,Cho Megan T.15,McWalter Kirsty15ORCID,Eyal Roy16ORCID,Hainlen Meagan K.6,Mendelsohn Bryce A.16ORCID,Porter Hillary M.17,Lanpher Brendan C.7,Lewis Andrea M.45,Savatt Juliann12,Thiffault Isabelle618ORCID,Callewaert Bert10ORCID,Campeau Philippe M.3ORCID,Yang Xiang-Jiao121920ORCID

Affiliation:

1. Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada.

2. Department of Medicine, McGill University, Montreal, Quebec H3A 1A3, Canada.

3. Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Quebec H3T 1C5, Canada.

4. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

5. Texas Children’s Hospital, 6701 Fannin Street, Houston, TX 77030, USA.

6. Center for Pediatric Genomic Medicine and Department of Clinical Genetics, Children’s Mercy Hospital, Kansas City, MO 64108, USA.

7. Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA.

8. Trillium Health Partners, Credit Valley Hospital, Genetics Program, 2200 Eglinton Ave. W, Mississauga, Ontario L5M 2N1, Canada.

9. Department of Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam, Netherlands.

10. Center for Medical Genetics, Ghent University and Ghent University Hospital, C. Heymanslaan 10, B-9000 Ghent, Belgium.

11. Clinical Genetics and Genomic Medicine, Geisinger, 100 N. Academy Ave., Danville, PA 17822, USA.

12. Autism and Developmental Medicine Institute, Geisinger, 120 Hamm Dr., Lewisburg, PA 17837, USA.

13. KAT6A Foundation, 3 Louise Dr., West Nyack, NY 10994, USA.

14. Texas Children’s Hospital, 6651 Main Street Legacy Tower, 21st Floor Houston, TX 77030, USA.

15. GeneDx, 207 Perry Parkway, Gaithersburg, MD 20877, USA.

16. Kaiser Oakland Medical Center 3600 Broadway, Oakland, CA 94611, USA.

17. Department of Genetics and Metabolism, Rare Disease Institute, Children’s National Hospital, 111 Michigan Avenue NW, Washington, DC 20010, USA.

18. Faculty of Medicine, University of Missouri Kansas City, Kansas City, MO 64110, USA.

19. Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada.

20. McGill University Health Center, Montreal, Quebec H3A 1A3, Canada.

Abstract

Two lysine acyltransferases govern histone H3 propionylation at lysine 23 in normal and pathological conditions.

Funder

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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