The chromatin remodeler ISWI acts during Drosophila development to regulate adult sleep

Author:

Gong Naihua N.1ORCID,Dilley Leela Chakravarti1ORCID,Williams Charlette E.1ORCID,Moscato Emilia H.1,Szuperak Milan1ORCID,Wang Qin2,Jensen Matthew34ORCID,Girirajan Santhosh345,Tan Tiong Yang67,Deardorff Matthew A.8910ORCID,Li Dong11ORCID,Song Yuanquan212ORCID,Kayser Matthew S.11314ORCID

Affiliation:

1. Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

3. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.

4. Bioinformatics and Genomics Program, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.

5. Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA.

6. Victorian Clinical Genetics Services, Murdoch Children’s Research Institute, Melbourne, Australia.

7. Department of Paediatrics, University of Melbourne, Melbourne, Australia.

8. Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

9. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

10. Department of Pathology and Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA.

11. Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

12. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

13. Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104 USA.

14. Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104 USA.

Abstract

A neurodevelopmental disorder-associated gene, ISWI/SMARCA5, acts during development to coordinate sleep later in life.

Funder

National Institutes of Health

Burroughs Wellcome Fund

Alfred P. Sloan Foundation

March of Dimes Foundation

Hearst Foundations

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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