A facile one-stage treatment of critical bone defects using a calcium sulfate/hydroxyapatite biomaterial providing spatiotemporal delivery of bone morphogenic protein–2 and zoledronic acid-Reference-Cited by-同舟云学术

A facile one-stage treatment of critical bone defects using a calcium sulfate/hydroxyapatite biomaterial providing spatiotemporal delivery of bone morphogenic protein–2 and zoledronic acid

Published:2020-11-27 Issue:48 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Raina Deepak Bushan¹^ORCID,Matuszewski Lucas-Maximilian²,Vater Corina²^ORCID,Bolte Julia²^ORCID,Isaksson Hanna¹³^ORCID,Lidgren Lars¹,Tägil Magnus¹^ORCID,Zwingenberger Stefan²^ORCID

Affiliation:

1. Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund 22185, Sweden.

2. University Hospital Carl Gustav Carus at Technische Universität Dresden, University Center of Orthopedic, Trauma and Plastic Surgery, Dresden 01307, Germany.

3. Lund University, Department of Biomedical Engineering, Lund 22100, Sweden.

Abstract

Combining BMP-2 and zoledronic acid is a recipe for creating “synthetic autologous bone” to treat large bone defects.

Funder

VINNOVA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. The challenge of establishing preclinical models for segmental bone defect research

2. The management of fractures with bone loss