Mechanisms of nuclear content loading to exosomes

Author:

Yokoi Akira1ORCID,Villar-Prados Alejandro12ORCID,Oliphint Paul Allen3ORCID,Zhang Jianhua4ORCID,Song Xingzhi4,De Hoff Peter5,Morey Robert56,Liu Jinsong7,Roszik Jason48ORCID,Clise-Dwyer Karen9,Burks Jared K.10ORCID,O’Halloran Theresa J.3,Laurent Louise C.56ORCID,Sood Anil K.111ORCID

Affiliation:

1. Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

2. Department of Medicine, Stanford University, Stanford, CA, USA.

3. Department of Molecular Biosciences and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.

4. Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

5. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.

6. Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA, USA.

7. Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

8. Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

9. Section of Transplant Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

10. Department of Leukemia and Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

11. Center for RNA Interference and Non-Coding RNA, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Abstract

Nuclear-derived exosomes generated by micronuclear collapse provide an accurate snapshot of genomic features in ovarian cancer.

Funder

National Institutes of Health

University of Texas MD Anderson Cancer Center

the Blanton-Davis Ovarian Cancer Research Program

American Cancer Society Research Professor Award

the Frank McGraw Memorial Chair in Cancer Research

Cancer Prevention Research Institute of Texas

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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