Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper

Author:

Mateescu Bogdan1,Kowal Emma J. K.2ORCID,van Balkom Bas W. M.3,Bartel Sabine4,Bhattacharyya Suvendra N.5,Buzás Edit I.6,Buck Amy H.7,de Candia Paola8,Chow Franklin W. N.7,Das Saumya9,Driedonks Tom A. P.10,Fernández-Messina Lola11,Haderk Franziska1213,Hill Andrew F.14ORCID,Jones Jennifer C.15ORCID,Van Keuren-Jensen Kendall R.16,Lai Charles P.17,Lässer Cecilia1819,di Liegro Italia20,Lunavat Taral R.1819,Lorenowicz Magdalena J.21,Maas Sybren L. N.18,Mäger Imre2223,Mittelbrunn Maria24,Momma Stefan25,Mukherjee Kamalika5,Nawaz Muhammad26,Pegtel D. Michiel27,Pfaffl Michael W.28,Schiffelers Raymond M.29,Tahara Hidetoshi30,Théry Clotilde31,Tosar Juan Pablo32,Wauben Marca H. M.10,Witwer Kenneth W.33ORCID,Nolte-‘t Hoen Esther N. M.10

Affiliation:

1. Department of Biology, Swiss Federal Institute of Technology Zurich (ETH Zürich), Zurich, Switzerland

2. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

3. Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, the Netherlands

4. Experimental Asthma Research, Priority Area Asthma & Allergy, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Borstel, Germany

5. Department of Science and Technology, CSIR-Indian Institute of Chemical Biology, Kolkata, India

6. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary

7. Institute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK

8. IRCCS MultiMedica, Milan, Italy

9. Cardiovascular Research Institute, Massachusetts General Hospital, Boston, MA, USA

10. Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

11. Immunology Service, Hospital La Princesa, Madrid, Spain

12. Department of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

13. Department of Medicine, Helen Diller Family Comprehensive Cancer Center, UC San Francisco, San Francisco, CA, USA

14. Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia

15. Molecular Immunogenetics & Vaccine Research Section, Vaccine Branch, CCR, NCI, Bethesda, MD, USA

16. Neurogenomics Division, TGen, Phoenix, AZ, USA

17. Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan

18. Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and NeuroDiscovery Center, Harvard Medical School, Boston, MA, USA

19. Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

20. Department of Experimental Biomedicine and Clinical Neurosciences (BIONEC), University of Palermo, Palermo, Italy

21. Center for Molecular Medicine, University Medical Center Utrecht & Regenerative Medicine Center, Utrecht, the Netherlands

22. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

23. Institute of Technology, University of Tartu, Tartu, Estonia

24. Instituto de Investigación del Hospital 12 de Octubre, Madrid, Spain

25. Institute of Neurology (Edinger Institute), Frankfurt University Medical School, Frankfurt am Main, Germany

26. Department of Pathology and Forensic Medicine, Ribeirão Preto School of Medicine, University of Sao Paulo, Sao Paulo, Brazil

27. Department of Pathology, Exosomes Research Group, VU University Medical Center, Amsterdam, the Netherlands

28. Animal Physiology and Immunology, School of Life Sciences, Technical University of Munich (TUM) Weihenstephan, Freising, Germany

29. Laboratory Clinical Chemistry & Haematology, University Medical Center Utrecht, Utrecht, the Netherlands

30. Department of Cellular and Molecular Biology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

31. Institut Curie, PSL Research University, INSERM U932, Paris, France

32. Functional Genomics Unit, Institut Pasteur de Montevideo, Nuclear Research Center, Faculty of Science, Universidad de la República, Montevideo, Uruguay

33. Department of Molecular and Comparative Pathobiology and Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Funder

National Cancer Institute

National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Histology

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