The 40 S -LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity-Reference-Cited by-同舟云学术

The 40 S -LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity

Published:2021-11-26 Issue:48 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Fuentes Pedro¹^ORCID,Pelletier Joffrey¹^ORCID,Martinez-Herráez Carolina¹²^ORCID,Diez-Obrero Virginia³⁴⁵⁶^ORCID,Iannizzotto Flavia¹^ORCID,Rubio Teresa¹^ORCID,Garcia-Cajide Marta¹,Menoyo Sandra¹^ORCID,Moreno Victor¹³⁴⁵⁶^ORCID,Salazar Ramón¹⁴⁵^ORCID,Tauler Albert¹²,Gentilella Antonio¹²^ORCID

Affiliation:

1. Laboratory of Cancer Metabolism, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.

2. Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.

3. Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO). Hospitalet de Llobregat, Barcelona, Spain.

4. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain.

5. Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.

6. Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL). L’Hospitalet de Llobregat, Barcelona, Spain.

Abstract

The mTOR-LARP1-5′TOP axis acts at the translational level as a primary guardian of the anabolic capacity of the cell.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference61 articles.

1. Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6

2. mTOR Signaling in Growth, Metabolism, and Disease

3. mTOR Signaling in Growth Control and Disease

4. Haematopoietic stem cells require a highly regulated protein synthesis rate

5. NUFIP1 is a ribosome receptor for starvation-induced ribophagy

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