Light-induced control of protein destruction by opto-PROTAC-Reference-Cited by-同舟云学术

Light-induced control of protein destruction by opto-PROTAC

Published:2020-02-21 Issue:8 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Liu Jing¹^ORCID,Chen He²^ORCID,Ma Leina¹^ORCID,He Zhixiang³^ORCID,Wang Dong¹^ORCID,Liu Yi¹⁴,Lin Qian¹,Zhang Tinghu³,Gray Nathanael³^ORCID,Kaniskan H. Ümit²,Jin Jian²^ORCID,Wei Wenyi¹^ORCID

Affiliation:

1. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

2. Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

3. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

4. Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Abstract

Opto-PROTAC adds a light-inducible switch on PROTAC, enabling optical control for targeted degradation of proteins of interest .

Funder

National Cancer Institute

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.