Cosmc deficiency causes spontaneous autoimmunity by breaking B cell tolerance-Reference-Cited by-同舟云学术

Cosmc deficiency causes spontaneous autoimmunity by breaking B cell tolerance

Published:2021-10-08 Issue:41 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zeng Junwei¹^ORCID,Aryal Rajindra P.¹^ORCID,Stavenhagen Kathrin¹^ORCID,Luo Chi²,Liu Renyan³,Wang Xiaohui⁴,Chen Jiaxuan¹^ORCID,Li Hao⁵^ORCID,Matsumoto Yasuyuki¹,Wang Yingchun⁶,Wang Jianmei⁶,Ju Tongzhong⁶,Cummings Richard D.¹^ORCID

Affiliation:

1. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

2. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

3. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

4. Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA.

5. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

6. Department of Biochemistry, Emory University, Atlanta, GA, USA.

Abstract

O-glycans on B cell glycoproteins controlled by X-linked Cosmc are required for B cell tolerance and preventing autoimmunity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference84 articles.

1. Altered B cell signalling in autoimmunity

2. B cells and autoimmunity

3. Recent insights in the epidemiology of autoimmune diseases: Improved prevalence estimates and understanding of clustering of diseases

4. Clonal selection and learning in the antibody system

5. Regulation of B-cell fate by antigen-receptor signals

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