Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids

Author:

Kalmykov Anna1ORCID,Huang Changjin23ORCID,Bliley Jacqueline1ORCID,Shiwarski Daniel1ORCID,Tashman Joshua1ORCID,Abdullah Arif4,Rastogi Sahil K.1ORCID,Shukla Shivani15ORCID,Mataev Elnatan1ORCID,Feinberg Adam W.15ORCID,Hsia K. Jimmy23ORCID,Cohen-Karni Tzahi15ORCID

Affiliation:

1. Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

2. School of Mechanical and Aerospace Engineering, Nanyang Technological University, 639798 Singapore, Republic of Singapore.

3. School of Chemical and Biomedical Engineering, Nanyang Technological University, 639798 Singapore, Republic of Singapore.

4. Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL 61801, USA.

5. Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Abstract

An organ-on-electronic chip (organ-on-e-chip)—a three-dimensional (3D) biosensor array to decipher tissue electrical activity.

Funder

National Science Foundation

National Institutes of Health

Office of Naval Research

Nanyang Technological University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

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2. M. C. LaPlaca V. N. Vernekar J. T. Shoemaker D. K. Cullen Three-dimensional neuronal cultures in Methods in Bioengineering: 3D Tissue Engineering J. R. Morgan F. Berthiaume Eds. (Artech House 2010) pp. 187–204.

3. Interactions of B16F10 melanoma cells aggregated on a cellulose substrate;Hindié M.;J. Cell. Biochem.,2006

4. Quantifying cellular traction forces in three dimensions

5. Cell migration strategies in 3-D extracellular matrix: Differences in morphology, cell matrix interactions, and integrin function;Friedl P.;Microsc. Res. Tech.,1998

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